Aquapro

GMP Hot Water Cascade Sterilizers

Aquapro hot water cascade sterilizers use the efficient heat transfer properties of recirculating water to deliver rapid sterilization cycles, while being gentle enough to prevent damaging or deforming products and packaging that may be sensitive to heat or pressure.

Rendering of a BMT USA Aquapro superheated water cascade sterilizer

Rapid and gentle terminal sterilization of liquid pharmaceuticals

Sterilization Process Overview

Aquapro sterilizers utilizes a high capacity water pump and large diameter piping to ensure high water flow rates. The recirculating water is heated and cooled by external heat exchangers. The heat exchangers are heated by plant steam and cooled by softened water as there is no direct contact with the recirculating chamber water. The recirculating water is directed to a perforated tray which evenly distributes the cascading water over the product. Due to the high flow rate of the cascading water, very even heat distribution is realized.

Key Features:

Rapid Sterilization
The efficient heat transfer properties of water allow for rapid heating and cooling times, significantly reducing the duration of the sterilization cycle when compared to the steam-air process.
Sanitary Stainless
The chamber, chamber door, sanitary piping and fittings are all constructed of 100% 316L stainless steel.
Non-Proprietary
Fully constructed with high-grade non-proprietary components for improved reliability, serviceability and value.
Compliance
Fully engineered and built in compliance with US FDA current Good Manufacturing Practice (cGMP), Good Automated Manufacturing Practice (GAMP), and US FDA CFR 21 Part 11.
Energy Efficient
The chamber and all piping systems are fully insulated to help maintain temperatures and reduce utility consumption.
PLC Controls
Industrial-grade Allen-Bradley or Siemens PLC-based control systems deliver reliable performance and repeatable operation.
Automatic Doors
Automatic pneumatic driven precision sliding chamber doors improve safety and convenience during operation.
Lubricant-Free Door Gasket
Lubricant-free door gaskets provide greater longevity and eliminate particle shedding into clean rooms.

Aquapro Terminal Sterilization Cycles

Aquapro sterilizers are programmed with a hot water cascade sterilization cycle with configurable parameters for each cycle phase. The programmed cycle recipe is stored in the sterilizer’s control system memory and is recalled and started with the touch of a button on the operator interface. All recipes are also protected from unauthorized changes via a multi-level authentication system.

Hot Water Cascade Cycle

The cycle begins with filling the chamber to a predetermined level with purified water. The water is circulated by a high capacity pump through an external heat exchanger that is heated by plant steam. The water is distributed through a perforation tray onto the product.  Due to the efficient heat transfer of the water, the product is heated rapidly. Compressed air at an over-pressure is injected into the chamber to compensate for the rising temperature and pressure that builds inside liquid containers when heated. At the end of the exposure step, cooling begins. The circulating water is cooled by an external heat exchanger that is cooled with cooling or chilled water. The load is quickly cooled to ambient temperature by continuously being sprayed with the circulating water. This method of sterilization is the fastest method for sterilization of liquids in sealed containers.

Configured to your exact requirements

BMT USA sterilizers can be fully configured to match almost any application, space, and layout requirements. Custom options for overall sterilizer size, service area access, and chamber capacity allow for perfect placement in your facility, while maintaining optimal loads — even in locations with space constraints. Additional options for single-door or pass-through models, floor or pit mounting, integrated or standalone steam generator, and custom sterilization cycle recipes further enhance the functionality and versatility of each unit.

Examples of Aquapro configuration options:

  • Custom chamber size & capacity.
  • Single-door or pass-through models. 
  • Floor or pit mounting.
  • Right or left service area access.
  • Integrated or remotely located controls cabinet. 
  • Integrated or standalone steam generator (electric or plant steam heated). 
  • Custom sterilization cycle recipes.
  • Loading equipment: shelves, trays, and trolleys.

Sterilizer Loading Equipment

BMT USA manufactures stainless steel loading equipment in standard or custom designs to accommodate any type of load. Our smaller chamber sizes can be equipped with wire or perforated shelves or loading racks, while large chambers can be equipped with loading carts and transfer trolleys. Large pit-mounted chamber include options for tracks and rub rails that can be designed to work with almost any type of wheel configuration on existing equipment. Carts with drop down wheels are also available for rooms with limited space.

Aquapro Chamber Sizes

Aquapro hot water cascade sterilizers are offered in a range of chamber sizes and volumes. The table below contains some of our standard models; however, we can design and build a customized solution to match your exact chamber capacity, exterior dimension, and mounting requirements.

Model

Chamber Dimensions

(W X H X D)

Chamber Volume

(ft³/m³)

Mountings

Door Slide Direction

P202038

Chamber Dimensions

20″ x 20″ x 38″
508 x 508 x 965 mm

Chamber Volume

8.8ft³/0.24m³

Mountings

Floor

Door Slide Direction

Vertical
P262639

Chamber Dimensions

26″ x 26″ x 39″
660 x 660 x 990 mm

Chamber Volume

15.8ft³/0.44m³

Mountings

Floor

Door Slide Direction

Vertical
P262649

Chamber Dimensions

26″ x 26″ x 49″
660 x 660 x 1245 mm

Chamber Volume

19ft³/0.54m³

Mountings

Floor

Door Slide Direction

Vertical
P263639

Chamber Dimensions

26″ x 36″ x 39″
660 x 915 x 990 mm

Chamber Volume

21ft³/0.59m³

Mountings

Floor

Door Slide Direction

Vertical or Horizontal
P263648

Chamber Dimensions

26″ x 36″ x 48″
660 x 915 x 1220 mm

Chamber Volume

25.9ft³/0.73m³

Mountings

Floor

Door Slide Direction

Vertical or Horizontal
P263660

Chamber Dimensions

26″ x 36″ x 60″
660 x 915 x 1524 mm

Chamber Volume

32.5ft³/0.92m³

Mountings

Floor

Door Slide Direction

Vertical or Horizontal
P363648

Chamber Dimensions

36″ x 36″ x 48″
915 x 915 x 1220 mm

Chamber Volume

36ft³/1.02m³

Mountings

Floor

Door Slide Direction

Horizontal
P363660

Chamber Dimensions

36″ x 36″ x 60″
915 x 915 x 1524 mm

Chamber Volume

45ft³/1.27m³

Mountings

Floor

Door Slide Direction

Horizontal
P375760

Chamber Dimensions

37″ x 57″ x 60″
940 x 1448 x 1524 mm

Chamber Volume

73.2ft³/2.07m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P375786

Chamber Dimensions

37″ x 57″ x 86″
940 x 1448 x 2184 mm

Chamber Volume

102.4ft³/2.9m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P484860

Chamber Dimensions

48″ x 48″ x 60″
1219 x 1219 x 1524 mm

Chamber Volume

80ft³/2.26m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P484872

Chamber Dimensions

48″ x 48″ x 72″
1219 x 1219 x 1829 mm

Chamber Volume

96ft³/2.72m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P484886

Chamber Dimensions

48″ x 48″ x 86″
1219 x 1219 x 2184 mm

Chamber Volume

114.5ft³/3.24m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P495748

Chamber Dimensions

49″ x 57″ x 48″
1219 x 1448 x 1219 mm

Chamber Volume

77.5ft³/2.19m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P495760

Chamber Dimensions

49″ x 57″ x 60″
1219 x 1448 x 1524 mm

Chamber Volume

96.9ft³/2.74m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P495772

Chamber Dimensions

49″ x 57″ x 72″
1219 x 1448 x 1829 mm

Chamber Volume

116.3ft³/3.29m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P495786

Chamber Dimensions

49″ x 57″ x 86″
1219 x 1448 x 2184 mm

Chamber Volume

155ft³/4.39m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P495796

Chamber Dimensions

49″ x 57″ x 96″
1219 x 1448 x 2438 mm

Chamber Volume

8.8ft³/0.24m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P488660

Chamber Dimensions

48″ x 86″ x 60″
1219 x 2184 x 1524 mm

Chamber Volume

143ft³/4.05m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P488686

Chamber Dimensions

48″ x 86″ x 86″
1219 x 2184 x 2184 mm

Chamber Volume

205ft³/5.8m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P548686

Chamber Dimensions

54″ x 86″ x 86″
1371 x 2184 x 2184 mm

Chamber Volume

230.7ft³/6.5m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal

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