Ventipro

GMP Steam-Air Mixture Sterilizers

Overview

Fast & Effective Terminal Sterilization of Packaged Pharmaceuticals

Ventipro steam-air mixture sterilizers offer faster heating and cooling times than conventional sterilizers, while also providing safe, and effective terminal sterilization of liquids in open, sealed, or heat-sensitive containers. Pure steam is utilized inside the chamber for heating the liquids and over-pressure filtered air is injected into the chamber to compensate for the rising temperature and pressure that builds inside the liquid container. Internal fans mix the chamber steam and air to ensure there are no cold pockets and to provide a uniform temperature distribution across the chamber. Rapid heating and cooling is achieved utilizing convection principles. At the end of the cycle, the product emerges dry and ready for labeling.
  • US FDA cGMP compliant
  • Extensive validation documentation
  • 316L stainless steel chambers with complete envelope 316L stainless steel jacket
  • Allen-Bradley or Siemens PLC control system
  • Temperature distribution better than +/- 0.5°C
  • Insulated chamber and piping reduces utility consumption
  • Automatic pneumatic driven precision sliding doors – chamber doors are solid 316L stainless steel and secured on all four sides
  • Lubricant free door gaskets
  • 21 CFR part 11 compliance for secure electronic data storage

Vertically Integrated Electric Clean Steam Generator Option

In addition to vertically integrated steam-to-steam generators, BMT USA is one of the only manufacturers also offering vertically integrated electric clean and pure steam generators up to a 400lb/hr capacity with a maximum output pressure of 80 PSIG. The vertical integration offers significant space savings while maintaining the same tight steam pressure control within +/- 2 PSIG of the set point.

P: 360-863-2252
E: Sales@BMTUSA.com

Ventipro Steam-Air Mixture Sterilizer with Controls Cabinet

Vertically Integrated Electric Clean Steam Generator Option

In addition to vertically integrated steam-to-steam generators, BMT USA is one of the only manufacturers also offering vertically integrated electric clean and pure steam generators up to a 400lb/hr capacity with a maximum output pressure of 80 PSIG. The vertical integration offers significant space savings while maintaining the same tight steam pressure control within +/- 2 PSIG of the set point.

P: 360-863-2252
E: Sales@BMTUSA.com

Engineered Features

BMT USA offers a range of features that enhance the efficiency, reliability, and serviceability of our sterilizers. Vertical and horizontal precision machined sliding doors are exceptionally smooth and provide a safer environment for operators. Door gaskets that reliably operate without the need for lubrication reduce maintenance and prolong life span. The chamber jacket design utilizes a unique beam construction that provides a complete envelope around the chamber. PLC-based control systems are intuitive and simple to operate, while providing the necessary sophistication for maximum flexibility and ease of validation.
Steam-Air Mixture fan assembly for GMP Steam Sterilizers

High Performance Fans

High performance fans intensify the streaming of the steam-air mixture through the chamber and around the load. The fan wheel and all components mounted inside the chamber are constructed of 316L stainless steel. The motor is installed outside the chamber and connected to the fan wheel with a unique sealing system that simplifies inspections and maintenance.

Ventipro Sterilization Cycles

Ventipro sterilizers can be programmed with vacuum drying and steam-air mixture sterilization cycles with configurable parameters for each cycle phase. The programmed cycle recipe is stored in the sterilizer’s control system memory and is recalled and started with the touch of a button on the operator interface. All recipes are also protected from unauthorized changes via a multi-level authentication system.


The dry good cycle provides effective sterilization of hard goods, filters, linens, and other porous materials, wrapped goods, and products that are unaffected by vacuum. The load is preconditioned utilizing vacuum and steam pulses. The cycle then advances to heat-up and continues until it reaches the settable exposure temperature of 110­°C up to 135°C. Once the exposure temperature set point is reached, the controller counts down the exposure time. After the exposure time is completed, drying begins and can be accomplished by fast exhaust and pulling a deep vacuum to remove moisture.



This cycle effectively sterilizes liquid products or items in vented or sealed containers. Heating occurs with steam while injecting compressed air to a preset differential over-pressure. The steam and air are circulated and mixed by the internal fans to ensure a rapid heat up to the user-configured exposure temperature, between 110°C and 135°C. The control of the air over-pressure is independent of the saturated steam pressure but corresponds to the temperature and pressure inside the load. Once the exposure temperature set point is reached, the controller counts down the exposure time. After the exposure countdown completes, the steam is stopped and cool air is blown across the load via the fans. During the cooling step, a preset support pressure is maintained in the chamber to prevent damage of the product containers . The load is cooled to a safe temperature and the pressure in the chamber is vented to atmosphere before the door can be opened.

Sterilizer Steam Source

BMT USA steam generators are constructed to cGMP guidelines and designed to provide pure or clean steam to meet the requirements of your sterilization application. The units can be configured as stand-alone units to be used a central source of steam for multiple units, or directly built into the sterilizer for a fully integrated solution. BMT USA steam generators utilize high grade non-proprietary components and can be electrically heated or heated by plant steam.

Electric Heated Steam

BMT USA electric clean steam generators are equipped with an ASME pressure vessel constructed from 316L stainless steel. The heating elements require three-phase voltage that can be specified at time of order. The units are equipped with an automatic blow-down system that carries impurities to drain. Feed water booster pumps are available when feed water is not available at the required pressure.

Steam-to-Steam

BMT USA steam-to-steam generators utilize plant steam as the heating source to produce clean steam. The tube and shell heat exchanger is made from 316L stainless steel and can be built in single-tube or double-tube configurations. The evaporator utilizes a wetted design that minimizes the temperature difference between the feed water and the heating steam, reducing stress on the evaporator tube sheet.

Sterilizer Loading Equipment

BMT USA manufactures stainless steel loading equipment in standard or custom designs to accommodate any type of load. Our smaller chamber sizes can be equipped with wire or perforated shelves or loading racks, while large chambers can be equipped with loading carts and transfer trolleys. Large pit-mounted chamber include options for tracks and rub rails that can be designed to work with almost any type of wheel configuration on existing equipment. Carts with drop down wheels are also available for rooms with limited space.
Steam Sterilizer Loading Cart with perforated shelves
Steam sterilizer perforated loading trays

Sterilizer Accessories & Options

Enhance your sterilizer’s functionality and maximize usable space with a range of sterilizer accessories and options, including 316L stainless steel perforated trays, steam quality sample cooler, printers, paperless videographic recorders, seismic restraint kits, additional operator interfaces, and electropolished chamber and piping finishes.

Ventipro Chamber Sizes

Ventipro Steam-Air Mixture Sterilizers are offered in a range of chamber sizes and volumes. The table below contains some of our standard models; however, we can design and build a customized solution to match your exact chamber capacity, exterior dimension, and mounting requirements.

Model

Chamber Dimensions

(W X H X D)

Chamber Volume

(ft³/m³)

Mountings

Door Slide Direction

P202038

Chamber Dimensions

20″ x 20″ x 38″
508 x 508 x 965 mm

Chamber Volume

8.8ft³/0.24m³

Mountings

Floor

Door Slide Direction

Vertical
P262639

Chamber Dimensions

26″ x 26″ x 39″
660 x 660 x 990 mm

Chamber Volume

15.8ft³/0.44m³

Mountings

Floor

Door Slide Direction

Vertical
P262649

Chamber Dimensions

26″ x 26″ x 49″
660 x 660 x 1245 mm

Chamber Volume

19ft³/0.54m³

Mountings

Floor

Door Slide Direction

Vertical
P263639

Chamber Dimensions

26″ x 36″ x 39″
660 x 915 x 990 mm

Chamber Volume

21ft³/0.59m³

Mountings

Floor

Door Slide Direction

Vertical or Horizontal
P263648

Chamber Dimensions

26″ x 36″ x 48″
660 x 915 x 1220 mm

Chamber Volume

25.9ft³/0.73m³

Mountings

Floor

Door Slide Direction

Vertical or Horizontal
P263660

Chamber Dimensions

26″ x 36″ x 60″
660 x 915 x 1524 mm

Chamber Volume

32.5ft³/0.92m³

Mountings

Floor

Door Slide Direction

Vertical or Horizontal
P363648

Chamber Dimensions

36″ x 36″ x 48″
915 x 915 x 1220 mm

Chamber Volume

36ft³/1.02m³

Mountings

Floor

Door Slide Direction

Horizontal
P363660

Chamber Dimensions

36″ x 36″ x 60″
915 x 915 x 1524 mm

Chamber Volume

45ft³/1.27m³

Mountings

Floor

Door Slide Direction

Horizontal
P375760

Chamber Dimensions

37″ x 57″ x 60″
940 x 1448 x 1524 mm

Chamber Volume

73.2ft³/2.07m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P375786

Chamber Dimensions

37″ x 57″ x 86″
940 x 1448 x 2184 mm

Chamber Volume

102.4ft³/2.9m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P484860

Chamber Dimensions

48″ x 48″ x 60″
1219 x 1219 x 1524 mm

Chamber Volume

80ft³/2.26m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P484872

Chamber Dimensions

48″ x 48″ x 72″
1219 x 1219 x 1829 mm

Chamber Volume

96ft³/2.72m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P484886

Chamber Dimensions

48″ x 48″ x 86″
1219 x 1219 x 2184 mm

Chamber Volume

114.5ft³/3.24m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P495748

Chamber Dimensions

49″ x 57″ x 48″
1219 x 1448 x 1219 mm

Chamber Volume

77.5ft³/2.19m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P495760

Chamber Dimensions

49″ x 57″ x 60″
1219 x 1448 x 1524 mm

Chamber Volume

96.9ft³/2.74m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P495772

Chamber Dimensions

49″ x 57″ x 72″
1219 x 1448 x 1829 mm

Chamber Volume

116.3ft³/3.29m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P495786

Chamber Dimensions

49″ x 57″ x 86″
1219 x 1448 x 2184 mm

Chamber Volume

155ft³/4.39m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P495796

Chamber Dimensions

49″ x 57″ x 96″
1219 x 1448 x 2438 mm

Chamber Volume

8.8ft³/0.24m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P488660

Chamber Dimensions

48″ x 86″ x 60″
1219 x 2184 x 1524 mm

Chamber Volume

143ft³/4.05m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P488686

Chamber Dimensions

48″ x 86″ x 86″
1219 x 2184 x 2184 mm

Chamber Volume

205ft³/5.8m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal
P548686

Chamber Dimensions

54″ x 86″ x 86″
1371 x 2184 x 2184 mm

Chamber Volume

230.7ft³/6.5m³

Mountings

Floor or Pit

Door Slide Direction

Horizontal

Ventipro Brochure

cGMP Steam Sterilizers