Products / Depyrogenation Ovens / Lytzen Class 5 (100) Depyrogenation Ovens

Lytzen

ISO Class 5 (100) Depyrogenation Oven

Overview

Dry heat sterilization and depyrogenation provide complete destruction of microorganisms by means of dry heat for a controlled period of time. Lytzen ISO Class 5 Depyrogenation Ovens are designed for critical depyrogenation applications in clean room areas, including the sterilization of empty glass and metal ampoules, injection bottles, vials, and stainless steel equipment. Lytzen depyrogenation ovens conform to ISO 14644-1, class 5 (formerly class 100) up to 280°C during the entire cycle.

Product Highlights:

  • Even temperature distribution without adjustments.
  • Manufactured in a ISO 9001 certified facility.
  • ISO class 5 compliance throughout the cycle – tested and documented before delivery of every sterilizer.
  • No temperature ramping needed during the heating or cooling phases of the cycle, significantly reducing overall cycle times.
  • High quality performance with low maintenance cost and reliable production.
  • Standard 24-months warranty on every unit.
Lytzen Depyrogenation Oven for Clean Rooms

ISO Class 5 Depyrogenation Oven Brochure

Lytzen Depyrogenation Ovens

Technical Data

Optimized Automatic Cycle

Lytzen Depyrogenation oven cycles are fully automatic and have been optimized to save energy.

Drying

The cycle starts with the drying phase where the damper on the exhaust is open, ensuring any moisture will be removed from the chamber.

Heating

Once the user-selected set-point temperature is reached, the damper will close and the temperature will quickly rise to the sterilizing set-point temperature. The damper will also stay closed during sterilization.

Each Lytzen oven is equipped with a powerful heating element to reduce heating time. Due to a superior filtration suspension system, the oven doesn’t need to ramp during heating and cooling phases, and can run at full speed to shorten the cycle time, while maintaining ISO class 5 conditions.

Sterilizing

The sterilizing timer can be started either by delay timer or load sensors. If load sensors are chosen, the sterilizing timer will only run if all load sensors are within an acceptable range from the sterilizing set-point.

Cooling

For applications where a reduced cycle time is necessary, forced air cooling or water cooling is available for rapid cooling times.

cGMP Design

As standard, Lytzen depyrogenation ovens are constructed with AISI 304 or 316L stainless steel inside and out, with different types of stainless steel also available to meet your specific requirements.

The oven’s water-cooling element is constructed of AISI 316L stainless steel and is a continuous welded unit without any connections inside the cabinet. The water-cooling element is also pressure tested to ensure reliable operation over the entire lifetime of the oven.

The chamber is fully welded inside to ensure no leakage to the insulation can occur and to simplify chamber cleaning. All welds are visible and can be inspected. The inside chamber is fully welded and assembled to the outside cabinet without use of screws and rivets, eliminating hidden crevices where particles and bacteria could generate and grow.
Depyrogenation Oven Stainless Steel Chamber
Depyrogenation Oven Door Gasket and Sealing System

Class 5 Testing

The critical phases for maintaining ISO class 5 are the heating and cooling phases due to the expansion and contracting of the frames around the filters. Particle counting during an entire cycle is therefore required over only counting during sterilizing or at ambient temperature.

Each depyrogenation oven is factory tested under simulated production conditions prior to shipping. A particle counter is used to test conformity with ISO Class 5 requirements. The chamber is tested for temperature distribution and pressure stability. Documentation of the testing is provided within the owner’s manual at delivery.

The kit for particle counting is also available to be ordered upon request.

Accessories

Lytzen Depyrogenation ovens can be ordered with a range of accessories, including transfer trolley, mobile rack, wire trays and cassettes.

Transfer Trolleys

The transfer trolley allows for transporting the mobile rack outside the chamber. The transfer trolley is locked to the chamber during loading to ease operation.

Mobile Racks

The mobile rack is available with fixed or removable tray supports. The height between the tray supports can be adjusted to suit customer load configurations. Additionally, the mobile rack is equipped with a smooth running wheel that can also withstand temperatures as high as 300 °C, without requiring lubricant.

Cassettes

The Cassettes can also be customized and are available in a perforated design. All mobile rack wire trays and cassettes are constructed with AISI 316L stainless steel.

ISO Class 5 Depyrogenation Oven Chamber Sizes

Lytzen depyrogenation ovens can be designed to meet your specific needs with flexible chamber size and capacity options. The listed models below are just a sample of the available standard sizes.

Model

Chamber Dimensions

(W X H X D)

External Dimensions

(W X H X D)

Chamber Volume

(m³)

LDF-590

Chamber Dimensions

700 x 800 x 1050 mm

External Dimensions

2205 x 1300 x 2405 mm

Chamber Volume

0.59m³
LDF-760

Chamber Dimensions

900 x 800 x 1050 mm

External Dimensions

2405 x 1300 x 2405 mm

Chamber Volume

0.76m³
LDF-920

Chamber Dimensions

800 x 800 x 1440 mm

External Dimensions

2305 x 1300 x 2795 mm

Chamber Volume

0.92m³
LDF-1540

Chamber Dimensions

100 x 1070 x 1440 mm

External Dimensions

2505 x 1570 x 2795 mm

Chamber Volume

1.54m³
LDF-2020

Chamber Dimensions

1000 x 1400 x 1440 mm

External Dimensions

2505 x 1900 x 2795 mm

Chamber Volume

2.02m³
LDF-2390

Chamber Dimensions

1000 x 1450 x 1650 mm

External Dimensions

2505 x 1950 x 3005 mm

Chamber Volume

2.39m³
LDF-2680

Chamber Dimensions

900 x 2070 x 1440 mm

External Dimensions

2405 x 2570 x 2795 mm

Chamber Volume

2.68m³
LDF-3190

Chamber Dimensions

900 x 2150 x 1650 mm

External Dimensions

2405 x 2650 x 3005 mm

Chamber Volume

3.19m³
LDF-3480

Chamber Dimensions

900 x 2150 x 1800 mm

External Dimensions

2405 x 2650 x 3155 mm

Chamber Volume

3.48m³
LDF-4010

Chamber Dimensions

900 x 2700 x 1650 mm

External Dimensions

2405 x 3200 x 3005 mm

Chamber Volume

4.86m³
LDF-4860

Chamber Dimensions

1400 x 1440 x 4525 mm

External Dimensions

4525 x 1900 x 2795 mm

Chamber Volume

4.03m³